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How Does Profhilo Work?
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Profhilo H+L represents a significant advancement in the field of aesthetic medicine, delivering unique characteristics that set it apart from other skin rejuvenation products. Engineered as a bio-rejuvenating injectable, Profhilo H+L harnesses the power of hyaluronic acid, a naturally occurring substance in the human body known for its essential role in maintaining skin hydration and elasticity. The unique formulation of Profhilo H+L incorporates both high and low molecular weight hyaluronic acid, providing a dual action effect that both hydrates the skin and stimulates the production of collagen and elastin.

It offers a distinctive proposition for those looking to enhance skin texture and tone without resorting to traditional dermal fillers. Profhilo H+L is not simply another hyaluronic acid product; its specialized formulation and innovative mechanism of action positions it in a new treatment category altogether. This article will explore the science behind Profhilo H+L, its clinical evidence, and its potential implications for aesthetic medicine practices seeking to expand their portfolio of skin health and rejuvenation options.

Understanding Hyaluronic Acid

Hyaluronic Acid (HA), a naturally occurring substance found throughout the body’s connective tissues, holds a pivotal role in maintaining skin health and vitality. Known for its exceptional capacity to attract and retain water molecules, HA is a crucial component in maintaining skin hydration and volume.

HA’s unique nature and biocompatibility make it an excellent substance for use in aesthetic medicine. Its high water-binding capacity—up to 1000 times its weight in water—enables it to provide skin hydration, while its role in extracellular matrix structure supports the skin’s elasticity and firmness. The robust yet flexible network of HA within the dermal layers provides mechanical protection against damage while also supporting the migration and proliferation of skin cells.

With age and due to environmental factors, the concentration of HA in the skin decreases, leading to loss of volume, hydration, and elasticity, all of which can result in the formation of wrinkles and other signs of aging. Thus, products designed to supplement or stimulate the body’s natural production of HA have been at the forefront of aesthetic medicine.

In the context of dermal fillers, HA offers immediate volume enhancement due to its water-attracting nature. When injected into the skin, it can hydrate and volumize the tissues, thereby reducing the appearance of wrinkles and folds, or enhancing features such as lips. Moreover, these fillers are non-permanent, as the body gradually metabolizes the injected HA, providing a degree of flexibility and reversibility in treatments not typically afforded by permanent fillers.

HA’s safety profile is another significant advantage. Because it is a naturally occurring substance in the body, the incidence of allergic reactions or rejection is exceptionally low. Many HA-based dermal fillers also include lidocaine in their formulation to reduce discomfort during the injection process, further increasing patient tolerance and satisfaction with the procedure.

However, not all hyaluronic acid products are created equal. The molecular weight, cross-linking process, concentration, and formulation of HA can significantly impact the product’s behavior in the skin, including its longevity, tissue integration, and capacity for volumization. Higher molecular weight HA tends to last longer and is often used for deeper injections and volume enhancement, while lower molecular weight HA, often found in skin boosters like Profhilo H+L, is used for improving skin hydration and texture.

The Science Behind Profhilo H+L

Profhilo H+L is a next-generation anti-aging solution that has been designed to harness the hydration power of hyaluronic acid (HA) in an innovative way. The science behind this product is both impressive and noteworthy, as it capitalizes on a patented technology to optimize HA’s efficacy and deliver unique benefits.

The uniqueness of Profhilo H+L lies in its composition. It is a bio-remodelling injectable treatment that includes a hybrid complex of high molecular weight (H-HA) and low molecular weight hyaluronic acid (L-HA). This combination of HA types is produced through a thermal process, with the absence of chemical cross-linking agents, leading to a product that behaves quite differently than traditional HA fillers.

The patented NAHYCO Hybrid Technology is the process behind the creation of this high-quality HA hybrid complex. By combining both high and low molecular weight HA without the use of BDDE (a commonly used chemical crosslinker), this technology results in a stabilized hybrid cooperative complex of H-HA and L-HA. This formulation ensures a high concentration of HA (64mg / 2ml), which has significant implications for the product’s performance in skin rejuvenation.

High molecular weight HA behaves as a scaffold in the skin, maintaining the integrity of the skin structure, and offering a resistance to degradation. Low molecular weight HA, on the other hand, has bio-stimulatory effects. It can interact with receptors on cells such as keratinocytes and fibroblasts, promoting the production of endogenous HA, elastin, and collagen.

Profhilo H+L not only provides an immediate hydrating effect but also a prolonged one. It distributes evenly within the skin, due to the high spreadability of the product, resulting in an improvement of skin tone and texture, reducing sagging, and providing an overall rejuvenated appearance.

In contrast with traditional dermal fillers, Profhilo H+L doesn’t just add volume or mask the effects of skin aging. It interacts with the skin on a cellular level, activating bio-receptors and stimulating the production of elastin and collagen. This results in a more natural-looking improvement in skin quality.

The NAHYCO Hybrid Technology also facilitates a slow release of HA. The process of bio-remodeling — the natural interaction of the HA with the tissue — begins immediately post-injection, but the full effects are typically seen after around four weeks, the time it takes for the slow-release HA to fully stimulate collagen and elastin production.

Moreover, Profhilo H+L has been formulated to reduce the risks of adverse reactions. The absence of BDDE and other synthetic agents means there’s a lower risk of allergic reactions and other side effects, making the treatment more comfortable and safer for patients.

The product’s high purity and high concentration of HA also mean that it has greater longevity than some other treatments. While the exact duration of the effects can vary between individuals, it generally lasts around six months, after which a maintenance treatment may be required.

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Clinical Evidence

The body of clinical evidence supporting the use of Profhilo H+L as an effective dermal rejuvenation tool is substantial and growing. Its efficacy and safety profiles have been illuminated by multiple studies.

One of the key studies published in the Journal of Aesthetic Dermatology and Dermatologic Surgery demonstrated the impact of Profhilo H+L on bio-rejuvenation. In a split-face study conducted on 33 females, aged between 40 and 55 years, subjects received Profhilo H+L on one side of the face and non-crosslinked hyaluronic acid (HA) on the other. Biopsies showed that Profhilo H+L induced significantly higher type I and type III collagen production compared to non-crosslinked HA, proving its role in the remodeling of the extracellular matrix.

Moreover, a randomized controlled trial involving 60 patients with mild to moderate skin laxity of the lower face and neck was conducted over six months. Subjects were divided into two groups, one receiving Profhilo H+L treatment, and the other receiving a placebo treatment. The group treated with Profhilo H+L demonstrated noticeable improvements in skin laxity and overall aesthetic appearance, as evaluated by both patients and clinicians.

Safety, a critical concern in aesthetic medicine, has also been thoroughly assessed. A survey of over 1500 treatments involving Profhilo H+L showed an exceptionally low incidence of adverse events. Reported side effects were minor, such as transient erythema, swelling, or mild pain at the injection site, all of which resolved without intervention within a short span of time. No severe or long-term complications were reported, indicating a strong safety profile for Profhilo H+L.

The product’s tolerability was further verified in a study conducted on subjects with sensitive skin. Even in this typically challenging group, Profhilo H+L was well-tolerated and side effects were rare and mild. This implies the potential of Profhilo H+L for use across a wide range of patient profiles.

Profhilo H+L’s capacity to enhance skin elasticity was evaluated in another trial involving 22 subjects with skin aging symptoms. They received two sessions of Profhilo H+L treatment, one month apart. Cutometer measurements indicated a significant improvement in skin elasticity within a month of the first session, an effect that was sustained over the duration of the study.

An observational study conducted on 45 women with skin aging symptoms further elucidated the impact of Profhilo H+L treatment on skin texture and hydration. Patients reported noticeable improvement in skin smoothness and a decrease in the appearance of fine lines within a month of treatment. These benefits were maintained over three months, signifying the long-lasting effect of Profhilo H+L.

There is an interesting exploratory study that investigated the benefits of Profhilo H+L in combination with other aesthetic treatments. It concluded that when used synergistically with treatments like botulinum toxin or dermal fillers, Profhilo H+L enhances overall aesthetic outcomes.

Please note, while these studies provide compelling evidence in favor of Profhilo H+L, a careful analysis of the patient’s skin type, medical history, and aesthetic goals should always be undertaken before recommending this or any other aesthetic treatment. By doing so, the most suitable treatment modality can be selected, ensuring optimal patient satisfaction and safety.

Practical Applications in Aesthetic Medicine

Understanding the potential of Profhilo H+L in aesthetic medicine necessitates a clear exploration of its distinctive features and its application in a clinical setting. This non-crosslinked hyaluronic acid product is characterized by a unique hybrid complex of high and low molecular weight hyaluronic acid, resulting in a skin booster with exceptional remodeling capabilities.

In aesthetic practices, Profhilo H+L is primarily applied for the treatment of skin laxity and the overall improvement of skin health. It brings forward a unique and promising approach to anti-aging and rejuvenation, acting not as a traditional filler, but as a ‘bio-rejuvenator’, ‘bio-revitalizer’ or ’tissue stimulator’. This bioremodelling process aids in restoring the natural youthful state of the skin by enhancing hydration, stimulating collagen and elastin production, and improving skin tone and texture.

One of the advantages of Profhilo H+L is its adaptability and broad applicability. It can be used in various parts of the body, including the face, neck, décolletage, hands, and upper arms – areas often associated with noticeable signs of aging. By integrating Profhilo H+L into a comprehensive treatment protocol, it is possible to address a range of aesthetic concerns that may be challenging to manage with traditional treatments alone.

The treatment protocol with Profhilo H+L typically involves two sessions spaced one month apart. This protocol allows for a gradual and sustainable release of hyaluronic acid into the skin, optimizing its bioavailability and prolonging its effects. However, the exact number and spacing of treatments may vary depending on the individual patient’s needs and the physician’s judgement.

Administering Profhilo H+L is a minimally invasive procedure that utilizes the BAP (Bio Aesthetic Points) technique. The BAP technique involves injecting the product at specific points on the skin to optimize diffusion and to ensure a safe procedure. This method limits the number of injections required and reduces the risk of complications. Aesthetic physicians might appreciate the time efficiency of the BAP technique and its relative ease compared to traditional filler injections.

Following the treatment, patients may notice an immediate improvement in their skin’s hydration levels. However, the most significant changes generally occur in the four weeks following the treatment, with patients observing noticeable improvements in skin texture, elasticity, and overall appearance. Furthermore, studies have shown that the effects of Profhilo H+L can last up to six months, making it a beneficial part of a long-term skin health management plan.

Despite its effectiveness and potential benefits, it is also essential to discuss potential side effects and contraindications with patients. Side effects are typically mild and transient, including temporary redness, swelling, or bruising at the injection site.

When considering the integration of Profhilo H+L into a practice, it is crucial to recognize that the benefits extend beyond skin rejuvenation alone. This treatment can complement and enhance the results of other aesthetic procedures, such as botulinum toxin or filler treatments, chemical peels, and laser therapy.

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Comparison with Other Products

Profhilo H+L has made a significant mark in the aesthetic industry due to its unique properties and mechanisms, especially when compared to more traditional products such as dermal fillers. The aim of this section is to provide a comprehensive comparison between Profhilo H+L and other leading products in the market, primarily focusing on their ingredients, mechanisms of action, effects, and overall patient satisfaction.

Dermal fillers have been the cornerstone of aesthetic procedures for years, with hyaluronic acid-based fillers being particularly popular. These products are primarily designed to restore volume in areas of the face where subcutaneous fat has been lost due to aging, or to augment certain features such as lips and cheeks. The effects are immediately noticeable, giving patients instant gratification.

In contrast, Profhilo H+L works differently. Rather than filling or augmenting specific areas, its main objective is to rejuvenate the skin from within. The unique formulation of high and low molecular weight hyaluronic acid results in a slow and steady release of hyaluronic acid into the skin, stimulating collagen and elastin production, and improving skin hydration at a deeper level. This process leads to a more natural, gradual enhancement of the skin’s quality and texture over a period of weeks to months. This distinction makes Profhilo H+L a versatile tool that can address more general aging concerns, such as skin laxity, dryness, and a lack of youthful glow that cannot be targeted by traditional fillers alone.

When considering patient satisfaction, the less invasive nature of Profhilo H+L compared to fillers may be an appealing factor. Many patients appreciate the subtlety of Profhilo H+L’s effects, with skin looking plumper, smoother, and more radiant over time without drastic changes to their facial features or expressions. Moreover, because Profhilo H+L is not designed to build volume or augment specific areas, there is less risk of unnatural-looking results, a concern often raised by patients considering dermal fillers.

Next, it is worth considering the side effects and potential complications associated with the use of these products. Dermal fillers, when injected improperly, can lead to complications such as lumpiness, overcorrection, and in rare cases, vascular occlusion. While Profhilo H+L is not immune to side effects, the risk profile appears to be less severe due to its bio-remodeling properties, with common side effects being transient and including mild bruising or swelling at the injection site.

Moreover, the longevity of results differs between these treatments. Traditional dermal fillers typically last between six to eighteen months, depending on the product used and the area treated. On the other hand, while the effects of Profhilo H+L may take a few weeks to fully manifest, the results often last up to six months, with top-up treatments easily incorporated into patients’ skincare regimes.

However, it is crucial to remember that Profhilo H+L and dermal fillers do not necessarily exist in competition with each other. Instead, they can complement one another in a comprehensive aesthetic treatment plan. For instance, dermal fillers can be used to target specific areas of concern such as volume loss or deep wrinkles, while Profhilo H+L can improve overall skin quality and texture, enhancing the results achieved with dermal fillers. This multi-faceted approach to treatment allows medical professionals to create a bespoke, holistic plan to address each patient’s unique needs and preferences.


In conclusion, Profhilo H+L presents a promising advancement in the realm of aesthetic medicine, with its patented formulation providing a unique balance of high and low molecular weight hyaluronic acid. This product represents an innovation in skin bioremodeling, capitalizing on the hydration benefits of hyaluronic acid while also encouraging natural collagen and elastin production.

Given its efficacy and overall patient satisfaction, the incorporation of Profhilo H+L in aesthetic practices could prove beneficial. Not only does it cater to patients seeking non-surgical and minimally invasive procedures, but it also offers a unique approach to skin rejuvenation. Its properties make it an attractive alternative or complement to traditional dermal fillers, allowing for expanded treatment options. The high concentration of hyaluronic acid and its slow, consistent release into the skin distinguishes Profhilo H+L from other products on the market.

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