Hyaluronic acid-based injectables serve diverse purposes in aesthetics, from adding structural volume to enhancing superficial skin quality. While traditional HA fillers primarily provide immediate fill, treatments like Jalupro® and Profhilo® focus on biorevitalization – specifically targeting the skin’s intrinsic hydration, elasticity, and radiance.

These two leading injectable treatments, though both utilizing HA, feature distinct formulations and mechanisms that result in different clinical applications and require different techniques. Understanding this Jalupro vs Profhilo comparison is essential for practitioners selecting the most appropriate treatment for their patients’ skin quality concerns.

Understanding the Products: Composition & Technology

The core differences between Jalupro® and Profhilo® begin at the molecular level:

A. Jalupro®

• Composition: Jalupro is a sterile, resorbable injectable composed of two key components: non-cross-linked Hyaluronic Acid and a specific, patented blend of Amino Acids (typically Glycine, L-Proline, L-Lysine, L-Leucine). It comes in different formulations (e.g., Jalupro Classic, Jalupro HMW – High Molecular Weight) with varying HA concentrations and molecular weights, but the amino acid blend is a consistent feature.
• Rationale: The HA component provides immediate hydration by attracting water. The amino acid mesotherapy blend provides essential precursors (building blocks) that fibroblasts need to synthesize collagen and elastin. This unique combination is aimed at nourishing the extracellular matrix and directly supporting fibroblast function.

B. Profhilo®

• Composition: Developed by IBSA, Profhilo utilizes a unique, patented NAHYCO® Hybrid Technology. This creates a stable, injectable HA complex by thermally bonding High Molecular Weight (HMW) and Low Molecular Weight (LMW) non-cross-linked HA chains, crucially without using chemical cross-linking agents like BDDE. It contains a very high concentration of HA (64mg per 2ml syringe).
• Rationale: The high concentration and unique hybrid complex provide intense, multi-level hydration. More significantly, this specific HA structure and high concentration stimulate fibroblasts, keratinocytes, and adipocytes, leading to significant stimulation of endogenous collagen and elastin production – a process termed “bioremodelling”. Its lack of chemical cross-linking results in high spreadability within tissues.

Mechanism of Action: How They Improve Skin Quality

Both products enhance skin quality, but their primary mechanisms differ:

• Jalupro® Dual Action: The non-cross-linked HA hydrates the skin. The amino acid cluster provides direct nutritional support to fibroblasts, optimizing their environment and providing the necessary “food” for them to function efficiently and produce new collagen and elastin. It works by nourishing the existing cellular machinery and the extracellular matrix.
• Profhilo® Bioremodelling: The highly concentrated and unique hybrid HA complex acts as a powerful signaling molecule. It stimulates a comprehensive regenerative response in the skin tissue, actively inducing the production of new collagen and elastin (“bioremodelling”). It works by initiating a broader tissue regeneration process.

The key difference lies in Jalupro providing precursors and hydration (nourishing/hydrating), while Profhilo provides intense HA stimulation to remodel the tissue architecture and hydrate profoundly (bioremodelling/hydrating).

Clinical Indications & Treatment Areas

While both improve skin quality, their ideal applications and common injection patterns differ:

• Jalupro® Indications: Primarily used for general skin revitalization, improving texture, elasticity, and hydration. Effective for reducing the appearance of fine lines and addressing initial signs of photoaging. Also used off-label for stretch marks or as an adjunct to other treatments.
• Jalupro® Areas: Can be used on the face, neck, décolletage, hands, underarms, inner thighs, and abdomen. Due to its composition and lower viscosity, it is often administered via superficial intradermal injections using broad mesotherapy techniques over larger areas.
• Profhilo® Indications: Specifically positioned for treating skin laxity (crepiness), improving hydration, skin tone, texture, and elasticity. Particularly effective for areas prone to laxity like the lower face, neck, and arms.
• Profhilo® Areas: Most commonly used on the face and neck utilizing the specific BAP (Bio Aesthetic Points) injection technique designed for maximal diffusion from fewer injection points. Also used on hands, arms, knees, and abdomen.

Jalupro is often associated with broader area revitalization via amino acid mesotherapy and hydration, while Profhilo is strongly linked to improving skin laxity and comprehensive hydration diffusion via its BAP technique.

Treatment Protocols & Injection Techniques

The recommended injection techniques and typical treatment protocols are a major distinction:

• Jalupro® Technique: Typically administered via multiple superficial intradermal injections, often using mesotherapy techniques such as micro-papules, linear threading, or fanning patterns across the treatment zone.
• Jalupro® Protocol: Usually requires an initial course of treatments, often 3-4 sessions spaced 1-2 weeks apart, followed by maintenance sessions every few months (e.g., 4-6 months).
• Profhilo® Technique: Characteristically injected using the standardized BAP technique – 5 specific injection points per side of the face or neck, delivering a precise small volume (0.2ml) per point into the deep dermis/subcutaneous layer. Designed to allow the product to spread widely from these strategic points.
• Profhilo® Protocol: The standard protocol is typically 2 treatment sessions spaced one month apart, followed by maintenance sessions every approximately 6 months.

This difference in approach – multi-point mesotherapy injections for Jalupro versus the specific, limited BAP points for Profhilo – is a key factor in practitioner choice and training requirements.

Expected Outcomes & Longevity

Both treatments offer skin quality improvement, but the emphasis may differ:

• Jalupro®: Patients typically observe gradual improvement in skin texture, hydration, elasticity, and reduction in fine lines. Results build over the treatment course. Longevity of the clinical effect is often cited around 6 months post-completion of the initial series, necessitating maintenance.
• Profhilo®: Often provides a noticeable improvement in hydration and skin ‘glow’ relatively quickly. More significant improvement in skin laxity and elasticity appears gradually over weeks/months as bioremodelling occurs. Longevity of clinical effects is often cited around 6-9 months post-initial series, requiring maintenance.

Neither offers the dramatic volume increase of traditional fillers. Profhilo is often highlighted for its specific effectiveness in improving skin laxity and crepiness, while Jalupro may be seen as providing broader nutritional revitalization and hydration.

Patient Selection Criteria

Choosing between Jalupro® and Profhilo® depends on the patient’s specific concerns and goals:

• Jalupro®: Suitable for patients seeking general skin revitalization, a hydration boost, improvement in fine lines, and addressing early signs of aging or photodamage. It is also a good option for younger patients seeking preventative treatments or those looking to improve skin quality in multiple body areas.
• Profhilo®: Particularly suitable for patients with noticeable signs of skin laxity (crepiness, sagging), dehydration, and loss of elasticity who are seeking a comprehensive bioremodelling effect.

A thorough assessment of the patient’s primary concern (hydration levels, degree of laxity, prominence of fine lines), skin condition, age, and expectations is essential.

Safety Profile & Side Effects

Both Jalupro® and Profhilo® are generally considered safe and well-tolerated when administered correctly by trained medical professionals. As they are based on HA, they share some potential side effects with HA fillers.

• Common Effects: Temporary redness, swelling, bruising, tenderness, and small, transient papules or blebs at the injection sites are common (especially with the multi-point mesotherapy approach for Jalupro, usually resolving quickly).
• Specific Risks: Allergy/hypersensitivity is rare. Infection is a risk with any injection if aseptic technique is compromised. Nodule formation is very rare with these types of non-cross-linked or minimally modified HA gels compared to more cohesive fillers, but adherence to correct depth and technique is still important. While the injection depths/techniques (superficial/intradermal/BAP) are designed to minimize vascular risk, awareness of anatomy is still needed.
• Contraindications: Standard HA contraindications (allergies, active infection near site).

Sourcing & Authenticity

As with all injectable aesthetic products, ensuring you purchase genuine Jalupro® and Profhilo® from reputable, authorized suppliers in your region is crucial. Counterfeit or substandard biorevitalizers can lead to unpredictable results, adverse reactions, and serious safety issues. Always verify your source when looking to buy Jalupro online supplier options or trying to order Profhilo authentic product for your practice.

Conclusion: Choosing Between Jalupro® and Profhilo®

Jalupro® and Profhilo® represent two effective, yet distinct, strategies within the growing field of injectable skin quality treatments. Jalupro offers a unique combination of HA hydration and amino acid fibroblast support, often delivered via mesotherapy for broad revitalization. Profhilo utilizes a high concentration of hybrid HA for powerful bioremodelling and intense hydration, typically administered via the specific BAP technique for improving laxity and texture.

Neither is universally “better”; the optimal choice depends entirely on a careful assessment of the patient’s primary skin concerns, treatment goals, and the practitioner’s expertise with the specific product’s technique and mechanism. Both are valuable tools for practitioners seeking to offer advanced aesthetic biorevitalization.

Doris Dickson

About the Author: Doris Dickson is a specialist writer for Health Supplies Plus, focusing on the aesthetic medicine industry. She diligently researches cosmetic treatments and products to provide clear, concise information relevant to licensed medical professionals. Her work supports Health Supplies Plus’s commitment to being a reliable informational resource and trusted supplier for the aesthetic community.

 

Disclaimer: The content provided in this article is intended for informational purposes only and is directed towards licensed medical professionals. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment, nor does it constitute an endorsement of any specific product or technique. Practitioners must rely on their own professional judgment, clinical experience, and knowledge of patient needs, and should always consult the full product prescribing information and relevant clinical guidelines before use. Health Supplies Plus does not provide medical advice.