Rejuran vs. Traditional Fillers: What’s the Difference?

Rain General January 13, 2025

The field of aesthetic medicine continues to innovate, offering cosmetic professionals a wider range of treatments to address diverse patient needs. Rejuran and traditional dermal fillers are both popular options, each offering unique benefits. While traditional fillers focus on volume restoration, Rejuran provides regenerative benefits aimed at improving skin health. This article examines the key differences between these treatments, equipping medical professionals with the insights needed to guide patient decisions effectively.

What is Rejuran?

Rejuran is a skin rejuvenation treatment that uses Polydeoxyribonucleotide (PDRN), a substance derived from salmon DNA, known for its regenerative properties. Its primary mechanism involves repairing damaged skin cells, stimulating collagen production, and promoting overall skin health. Unlike volume-enhancing dermal fillers, Rejuran focuses on cellular repair, improving skin elasticity, hydration, and texture over time.

Rejuran is commonly used to address fine lines, enlarged pores, and thin, damaged skin. Its regenerative properties make it ideal for patients seeking subtle, natural-looking improvements in skin quality. Popular in Asian markets, Rejuran is gaining recognition globally for its ability to create the ‘glass skin’ look—smooth, radiant, and youthful.

What Are Traditional Dermal Fillers?

Traditional dermal fillers, such as Juvederm, Restylane, and Belotero, are injectable treatments primarily composed of hyaluronic acid (HA). Their main purpose is to restore facial volume, contour features, and smooth static wrinkles by physically filling spaces beneath the skin’s surface. Unlike Rejuran, which works on cellular repair, fillers deliver immediate aesthetic improvements.

These fillers can plump lips, smooth out under-eye hollows, and define the jawline, making them versatile for enhancing various facial features. With effects lasting anywhere from 6 to 18 months, depending on the product and treatment area, HA fillers are a versatile option for patients seeking dramatic yet natural-looking enhancements.

Key Differences Between Rejuran and Traditional Fillers

Composition

Rejuran: Composed of PDRN, which has anti-inflammatory and regenerative properties.
Traditional Fillers: Made of HA, a hydrating molecule that provides volume and structure.

Mechanism of Action

Repairs and rejuvenates skin at the cellular level by promoting collagen synthesis and improving skin texture.
Traditional Fillers**: Physically fill volume-deficient areas to restore contour and smooth wrinkles.

Treatment Goals

Rejuran: Targets overall skin health, including elasticity, hydration, and texture.
Traditional Fillers: Focuses on immediate volume restoration and wrinkle reduction.

Results Timeline

Rejuran: Gradual results develop over weeks as the skin regenerates.
Traditional Fillers: Instant results with visible changes immediately after the procedure.

Indications

Rejuran: Suitable for patients seeking subtle, natural skin rejuvenation.
Traditional Fillers: Ideal for patients with volume loss, deep wrinkles, or those seeking dramatic contouring.

Clinical Considerations for Rejuran vs. Traditional Fillers

Patient Selection

Rejuran is ideal for younger patients or those with mild skin concerns who prioritize natural improvements. Conversely, traditional fillers are better suited for individuals with moderate-to-severe volume loss or pronounced wrinkles.

Treatment Protocols

Rejuran typically requires a series of 3-4 treatments spaced 2-4 weeks apart for optimal results. Traditional fillers often achieve desired outcomes in a single session, with periodic touch-ups needed to maintain effects.

Combination Therapies

For patients with complex aesthetic goals, combining Rejuran with traditional fillers can deliver comprehensive results. While Rejuran enhances skin quality, fillers provide the structural support needed for facial contouring.

Side Effects and Downtime

Side effects with Rejuran are usually mild and temporary, like a little redness or swelling that goes away in 1-2 days. Traditional fillers may cause bruising or swelling, with downtime varying depending on the treatment area.

Practical Guidance for Cosmetic Professionals

When determining the right treatment for patients, consider their aesthetic goals, skin condition, and expectations. Rejuran is an excellent choice for preventative care and long-term skin health, while traditional fillers are ideal for patients seeking immediate, targeted enhancements. Educating patients about the benefits of each option can help them make informed decisions and achieve satisfying outcomes.

Conclusion

Rejuran and traditional fillers serve distinct roles in aesthetic medicine, each offering unique benefits to patients. Rather than viewing them as competing treatments, consider their complementary potential. Rejuran’s regenerative properties and traditional fillers’ volume-restoring capabilities can work in harmony to achieve both immediate and long-term aesthetic goals. By incorporating both into your practice, you can elevate patient satisfaction and expand your treatment portfolio. Licensed medical practitioners can buy Rejuran at Health Supplies Plus.

Rejuran Frequently Asked Questions

1. What is Rejuran, and how does it differ from traditional fillers?

Rejuran is a regenerative skin treatment using PDRN to repair and rejuvenate the skin, while traditional fillers focus on restoring volume and contour.

2. Who are ideal candidates for Rejuran?

Ideal candidates are younger patients or those seeking subtle, natural improvements in skin texture and quality.

3. What are the main benefits of Rejuran?

Rejuran improves skin elasticity, hydration, and texture while promoting collagen production for long-term skin health.

4. How long does it take to see results with Rejuran?

Results develop gradually over weeks as the skin regenerates and collagen synthesis occurs.

5. How do traditional fillers work?

Traditional fillers use hyaluronic acid to add volume and smooth wrinkles by filling spaces beneath the skin.

6. What areas are typically treated with Rejuran?

Rejuran is commonly used on the face, neck, and décolletage to address fine lines, enlarged pores, and damaged skin.

7. What areas are typically treated with traditional fillers?

Common areas include the lips, cheeks, under-eye hollows, nasolabial folds, and jawline.

8. Can Rejuran and traditional fillers be combined?

Yes, combining Rejuran and fillers can provide comprehensive results, enhancing skin quality while restoring volume and contour.

9. What is the downtime for Rejuran treatments?

Downtime is minimal, with mild redness or swelling resolving within 1-2 days.

10. What is the downtime for traditional filler treatments?

Downtime varies but may include bruising or swelling, depending on the treatment area.

11. How many Rejuran sessions are typically required?

Most patients require 3-4 sessions spaced 2-4 weeks apart for optimal results.

12. How long do traditional fillers last?

The effects of traditional fillers last 6 to 18 months, depending on the product and area treated.

13. Are there any risks associated with Rejuran?

Rejuran has minimal risks, with mild redness or swelling being the most common side effects.

14. Are there any risks associated with traditional fillers?

Potential risks include bruising, swelling, and, in rare cases, uneven results or overfilling.

15. How should patients prepare for Rejuran treatments?

Patients should avoid alcohol and anti-inflammatory medications before treatment to reduce the risk of bruising.

16. How should patients prepare for traditional filler treatments?

Similar to Rejuran, patients should avoid alcohol, blood-thinning medications, and supplements before treatment.

17. How does Rejuran promote collagen production?

Rejuran’s PDRN stimulates fibroblasts in the skin, encouraging collagen synthesis for improved elasticity and texture.

18. How quickly do patients see results with traditional fillers?

Results with traditional fillers are immediate, with full effects visible once swelling subsides.

19. Can Rejuran be used for preventative care?

Yes, Rejuran is excellent for maintaining skin health and preventing early signs of aging.

20. Are traditional fillers suitable for younger patients?

Yes, fillers can be used for subtle enhancements like lip augmentation or contouring in younger patients.

21. What makes Rejuran popular in Asian markets?

Rejuran’s focus on achieving the “glass skin” look aligns with the beauty standards of smooth, radiant, and natural-looking skin.

22. Are the effects of Rejuran permanent?

No, the effects are not permanent, but regular maintenance treatments can sustain results.

23. Are the effects of traditional fillers permanent?

No, traditional fillers are temporary and require periodic touch-ups to maintain results.

24. What is the primary purpose of Rejuran?

Rejuran’s primary purpose is to improve skin quality by repairing damaged cells and promoting collagen production.

25. What is the primary purpose of traditional fillers?

Traditional fillers are designed to restore lost volume, contour facial features, and smooth wrinkles.