With the rise of regenerative injectables, more aesthetic professionals are exploring treatments that go beyond traditional fillers. Rejuran and skin boosters have become two of the most sought-after options for non-surgical skin rejuvenation, but they serve different purposes. Rejuran works on deep skin repair and collagen regeneration, while skin boosters, such as Restylane Skinboosters and Juvederm Volite, provide intense hydration and a youthful glow. Understanding the differences between these treatments can help practitioners choose the best option for each patient.
What Is Rejuran? Understanding Polynucleotide-Based Skin Healing
Rejuran is a regenerative injectable derived from salmon DNA (polynucleotides). It works by stimulating fibroblasts to produce more collagen and elastin, helping to repair damaged skin, improve elasticity, and reduce signs of aging. Unlike hyaluronic acid fillers, which provide volume and hydration, Rejuran focuses on long-term skin restoration.
Rejuran is commonly used for:
- Reducing fine lines and wrinkles
- Improving skin elasticity and thickness
- Minimizing acne scars and pigmentation
- Enhancing overall skin texture
What Are Skin Boosters? Hydration and HA-Based Skin Rejuvenation
Skin boosters, on the other hand, are hyaluronic acid-based injectables designed to deeply hydrate the skin, improve elasticity, and create a radiant complexion. Unlike traditional fillers that add volume, skin boosters work by drawing moisture into the skin, plumping and smoothing fine lines.
Two of the leading HA-based skin boosters are:
- Restylane Skinboosters: Uses stabilized HA to provide long-lasting hydration and improve skin texture over time.
- Juvederm Volite: A high-performance HA-based booster that enhances hydration, smoothness, and elasticity for up to nine months.
Key Differences Between Rejuran and HA-Based Skin Boosters
Both Rejuran and HA skin boosters offer significant benefits, but they cater to different skin needs. Here’s how they compare:
| Feature | Rejuran | HA-Based Skin Boosters (Restylane Skinboosters & Juvederm Volite) |
|---|---|---|
| Primary Function | Skin repair, regeneration, and collagen stimulation | Deep hydration, plumping, and improved skin texture |
| Key Ingredient | Polynucleotides (PN) from salmon DNA | Hyaluronic acid (HA) |
| Results Timeline | Gradual improvement over 4-8 weeks | Immediate hydration with optimal results in 2-4 weeks |
| Longevity | 6-12 months | 6-9 months |
| Best For | Aging skin, acne scars, skin laxity | Dehydrated skin, fine lines, dull complexion |
| Injection Technique | Multiple micro-injections across the treatment area | Microinjections or mesotherapy technique |
Which Treatment Is Best for Your Patients?
The decision between Rejuran and HA-based skin boosters depends on the patient’s needs and skin concerns:
Choose Rejuran for Patients Who:
- Have damaged, aging, or scarred skin that needs deep repair
- Want firmer, more youthful skin over time rather than instant hydration
- Are looking for a long-term solution to improve skin quality
Choose HA-Based Skin Boosters for Patients Who:
- Need an immediate hydration boost for dry, dull skin
- Want a quick refresh before a special event
- Are in their 20s-40s looking for preventive skincare rather than deep repair
Can Rejuran and Skin Boosters Be Combined?
Yes! Many aesthetic clinics combine Rejuran and HA skin boosters for a comprehensive skin rejuvenation approach. Rejuran repairs and strengthens the skin, while HA-based boosters enhance hydration and radiance.
A common treatment plan includes:
- Rejuran first (for deep healing and collagen stimulation)
- Restylane Skinboosters or Juvederm Volite later (to enhance hydration and glow)
This combination is ideal for patients who want both skin repair and an instantly refreshed look.
Can Rejuran and Fillers Be Combined?
Yes, Rejuran can be safely combined with dermal fillers to achieve a comprehensive approach to facial rejuvenation. While Rejuran focuses on improving skin quality and elasticity by stimulating collagen production, dermal fillers such as Juvederm or Restylane add volume and contour specific areas of the face.
Many aesthetic professionals use a combined approach for patients looking for both skin enhancement and structural improvement. Here’s how the two treatments can complement each other:
- Rejuran: Improves skin texture, elasticity, and hydration over time, making the skin more resilient and youthful.
- Dermal Fillers: Add volume to areas like the cheeks, nasolabial folds, jawline, and lips for a more sculpted and lifted appearance.
The ideal treatment sequence typically involves using Rejuran first to strengthen and repair the skin, followed by dermal fillers to enhance facial structure. This approach ensures that the fillers last longer and sit better in well-nourished, healthy skin.
By combining Rejuran and fillers, aesthetic professionals can offer patients a more balanced and natural-looking anti-aging solution that enhances both skin quality and facial contours.
Conclusion
Rejuran and HA-based skin boosters serve different but complementary roles in aesthetic medicine. Rejuran is best for long-term skin regeneration and repair, while Restylane Skinboosters and Juvederm Volite provide deep hydration and radiance. Meanwhile, combining Rejuran with dermal fillers offers a powerful anti-aging solution that improves both skin quality and facial structure. Licensed medical professionals can buy Rejuran at Health Supplies Plus.