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Radiesse vs Juvederm Voluma: Which is the Best Dermal Filler?

Radiesse and Juvederm Voluma are FDA-approved dermal fillers for moderate to severe facial folds and wrinkles and nasolabial folds. Although both are known for their excellent lifting and volumizing effects, they contain different formulations and have different mechanisms of action.

Juvederm Voluma was the first facial filler approved specifically for addressing age-related volume loss in the cheeks. Radiesse was the first dermal filler to be FDA-approved for treating areas other than the face. It also corrects volume loss in the backs of the hands. For off-label uses, these products are also consistently being used for treatment of marionette lines and facial contouring.


  • Stimulates the production of new collagen by the body
  • Its synthetic polymer component is not as easily degraded by the body, which means its effects last longer than HA-based fillers
  • Can be used for hand rejuvenation
  • Its scaffolding-like structure supports the skin


  • Approved for cheek augmentation
  • Offered with a variant that contains lidocaine, avoiding the need for topical numbing creams
  • Specially formulated using Vycross Technology – offers the improved cross-linking efficiency of hyaluronic acid (HA) by combining high and low molecular weight HA
  • It draws more water to the treatment area than Radiesse because of its HA component
  • Overcorrection or undesirable effects can be reversed


Radiesse Voluma
Composition Calcium hydroxylapatite microspheres Crosslinked Hyaluronic acid
Safety Profile Generally safe, but complications may include nodule or bump formation Post-injection reactions (redness, swelling, tenderness, and bruising) have been reported
Results Provides great lifting effect and is good for correcting deeper lines Adds volume to the cheeks
Cost $600 to $800 $700 to $1,000
Duration Lasts up to 2 years Lasts between 6 to 12 months

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