RESTYLANE® REFYNE™

Where can I buy this product?

RESTYLANE® REFYNE™ w/ Lidocaine is available for purchase through Health Supplies Plus by licensed medical practitioners holding a valid medical license. First-time buyers can register an online account by providing required professional information. Account verification is typically completed within 2 business hours, after which you can purchase medical supplies at competitive wholesale pricing. Registered members may also be eligible for volume discounts and receive dedicated customer service support.

Product Information

What is RESTYLANE® REFYNE™ w/ Lidocaine?

RESTYLANE® REFYNE™ w/ Lidocaine is a sterile, injectable gel consisting of cross-linked hyaluronic acid (HA) of non-animal origin, manufactured by Galderma. It is specifically formulated using Galderma’s XpresHAn Technology™ (also known globally as OBT™). This technology creates a highly flexible and soft HA gel designed for smooth integration and support in dynamic facial areas, helping to maintain natural expression.

This FDA-approved formulation contains 20mg/mL of hyaluronic acid and includes 0.3% lidocaine hydrochloride to enhance patient comfort during the injection procedure. RESTYLANE® REFYNE™ is indicated in the US for injection into the mid-to-deep dermis for the correction of moderate to severe facial wrinkles and folds (such as nasolabial folds) in patients over the age of 21.

Storage: RESTYLANE® REFYNE™ w/ Lidocaine should be stored up to 25°C (77°F). Do not freeze. Protect from light.

Authenticity: Health Supplies Plus guarantees that all RESTYLANE® products are authentic, and handled according to manufacturer specifications.

How does RESTYLANE® REFYNE™ w/ Lidocaine work?

RESTYLANE® REFYNE™ utilizes XpresHAn Technology™ to produce an HA gel characterized by high flexibility and lower firmness (G’) compared to Restylane® Defyne™ or NASHA® products. This unique rheology allows the gel to integrate seamlessly within the dermis and flex naturally with facial expressions, helping to soften lines without significantly restricting movement.

When injected into the mid-to-deep dermis, it provides subtle volume and support to correct moderate wrinkles and folds, such as nasolabial folds and marionette lines, particularly where maintaining natural facial dynamics is a priority for the patient.

Treatment results are visible immediately. The duration of effect for RESTYLANE® REFYNE™ is clinically proven to last up to 12 months, although individual results may vary based on patient factors, injection site, and volume. The integrated lidocaine significantly improves patient comfort during the procedure.

Indications for Use

RESTYLANE® REFYNE™ w/ Lidocaine is indicated for patients over the age of 21 for:

• Correction of moderate to severe facial wrinkles and folds (e.g., nasolabial folds) where natural movement and flexibility are desired.

Primary Benefits

• High flexibility with XpresHAn Technology™ supports natural facial expressions.
• Effectively softens moderate wrinkles and folds (FDA-approved for nasolabial folds).
• Integrates smoothly into dermal tissue.
• Provides subtle support and correction.
• Offers results lasting up to 12 months (clinically proven).
• Contains lidocaine for improved patient comfort during injection.
• Side Effects and Safety Information

Common side effects observed in US clinical trials are typically mild to moderate, temporary, and related to the injection site, including:

• Swelling
• Lumps/bumps
• Bruising
• Redness
• Tenderness or Pain
• Itching

Severe Adverse Events:
As with any dermal filler injection, there are risks of more serious complications. Practitioners must possess thorough anatomical knowledge and be prepared to manage complications. Potential severe adverse events include:

• Vascular Occlusion (VO): Unintentional injection into a blood vessel can obstruct blood flow, potentially leading to tissue necrosis (tissue death), scarring, or (in rare cases involving facial arteries) blindness or stroke. Prompt recognition and management according to established protocols are crucial.
• Severe allergic reactions (anaphylaxis)
• Inflammation, infection, or abscess formation
• Granuloma or persistent nodule formation
• Migration of filler
• Prolonged pain or numbness
• Herpetic eruptions (cold sores) in susceptible individuals