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RESTYLANE® DEFYNE™

$209.00

RESTYLANE® DEFYNE™ w/ Lidocaine by Galderma utilizes OBT™/XpresHAn™ technology, providing flexible support for deeper facial lines (e.g., nasolabial folds, marionette lines) and chin augmentation. Contains 0.3% lidocaine. For professional use only.

Quantity Price
1 - 5 $209.00
6 - 10 $199.00
11 - 20 $194.00
21+ $189.00

Where can I buy this product?

RESTYLANE® DEFYNE™ w/ Lidocaine is available for purchase through Health Supplies Plus by licensed medical practitioners holding a valid medical license. First-time buyers can register an online account by providing required professional information, including medical license verification and a valid shipping address. Account verification is typically completed within 2 business hours, after which you can purchase medical supplies at competitive wholesale pricing. Registered members may also be eligible for volume discounts and receive dedicated customer service support. We are committed to ensuring all products are sourced and sold exclusively to qualified professionals.

Product Information

What is RESTYLANE® DEFYNE™ w/ Lidocaine?

RESTYLANE® DEFYNE™ w/ Lidocaine is a sterile, injectable gel consisting of cross-linked hyaluronic acid (HA) of non-animal origin, manufactured by Galderma. It is specifically formulated using Galderma’s OBT™ (Optimal Balance Technology), also known as XpresHAn Technology™. This technology creates a flexible yet supportive HA gel designed to integrate smoothly while effectively correcting deeper lines and augmenting facial contours.

This formulation typically contains 20mg/mL of hyaluronic acid and includes 0.3% lidocaine hydrochloride to enhance patient comfort during the injection procedure. RESTYLANE® DEFYNE™ is indicated for injection into the deep dermis to superficial subcutaneous plane for the correction of moderate to severe deep facial wrinkles and folds (such as nasolabial folds and marionette lines) and for augmentation of the chin region.

Storage: RESTYLANE® DEFYNE™ w/ Lidocaine should be stored up to 25°C (77°F). Do not freeze. Protect from light.

Authenticity: Health Supplies Plus guarantees that all RESTYLANE® products are authentic, sourced through appropriate channels, and handled according to manufacturer specifications.

Note: For professional use only.

How does RESTYLANE® DEFYNE™ w/ Lidocaine work?

RESTYLANE® DEFYNE™ employs the OBT™/XpresHAn Technology™ to produce an HA gel that balances supportive lift with flexibility. This allows it to effectively smooth deep wrinkles and folds, like prominent nasolabial folds and marionette lines, while still allowing for natural facial expression and movement. Compared to Restylane® Refyne™, Defyne provides more structural support.

When injected into the deep dermis or subcutaneous tissue, it integrates into the tissue, providing volume and support to lift and correct deep facial lines. It is also suitable for augmenting the chin, providing projection and shape while maintaining a degree of softness consistent with natural tissue.

Treatment results are visible immediately. The duration of effect for RESTYLANE® DEFYNE™ is clinically proven to last up to 12 months for wrinkles and folds, and also for chin augmentation, although individual results may vary. The integrated lidocaine significantly improves patient comfort during the procedure.

Indications for Use

RESTYLANE® DEFYNE™ w/ Lidocaine is indicated for adults (typically 21 years and older, consult local regulations/IFU) for:

  • Correction of moderate to severe, deep facial wrinkles and folds (e.g., nasolabial folds, marionette lines).
  • Augmentation of the chin region to improve the chin profile in patients with mild to moderate chin retrusion.

Appropriate patient selection, injection technique suitable for deeper placement, and consideration of contraindications outlined in the Instructions for Use (IFU) are essential.

Primary Benefits

  • Utilizes flexible OBT™/XpresHAn™ technology for natural expression.
  • Provides effective support for correcting deep facial wrinkles and folds.
  • Suitable for chin augmentation, improving projection and profile.
  • Offers results lasting up to 12 months.
  • Integrates smoothly while providing necessary structural support.
  • Contains lidocaine for improved patient comfort during injection.

Side Effects and Safety Information

Practitioners must consult the complete Instructions for Use (IFU) provided with the product for comprehensive information on indications, contraindications, warnings, precautions, and potential adverse events. It is essential to discuss all potential risks and side effects with patients prior to treatment. Proper injection technique and anatomical knowledge are crucial, especially when injecting deep or near critical structures like nerves and vessels.

Common side effects are typically mild to moderate, temporary, and related to the injection site, including:

  • Swelling
  • Bruising
  • Redness
  • Tenderness or Pain
  • Itching
  • Firmness or Lumps/Bumps (usually temporary)

Severe Adverse Events:
As with any dermal filler injection, particularly those involving deeper placement, there are risks of more serious complications. Practitioners must be prepared to manage potential complications. Potential severe adverse events include:

  • Vascular Occlusion (VO): Accidental injection into a blood vessel can obstruct blood flow, potentially leading to tissue necrosis (tissue death), scarring, or (in rare cases involving facial arteries) blindness or stroke. Prompt recognition and management according to established protocols are crucial.
  • Severe allergic reactions (anaphylaxis)
  • Inflammation, infection, or abscess formation
  • Nerve damage or impingement (due to deep injection, e.g., near mental nerve for chin augmentation)
  • Granuloma or persistent nodule formation
  • Migration of filler
  • Prolonged pain or numbness
  • Herpetic eruptions (cold sores) in susceptible individuals
Manufacturer

Galderma

Active Substance(s)

Hyaluronic acid, lidocaine

Strength

20mg/ml, 3mg/ml

Pack Size

1-1ml prefilled syringe

Accessories

Package insert, 2-27G 1/2” needles, 2 traceability labels

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