PROFHILO® H+L

Where can I buy this product?

PROFHILO® H+L is available for purchase through Health Supplies Plus by licensed medical practitioners. First-time buyers can register an online account by providing required professional information, including medical license verification and a valid shipping address. Account verification is typically completed within 2 business hours, after which you can purchase medical supplies at competitive wholesale pricing. Registered members may also be eligible for volume discounts and receive dedicated customer service support. We are committed to ensuring all products are sourced and sold exclusively to qualified professionals.

Product Information

What is PROFHILO® H+L?

PROFHILO® H+L is a sterile, injectable bioremodelling product developed by IBSA Farmaceutici Italia. It is uniquely formulated with a high concentration of ultra-pure hyaluronic acid (HA) utilizing IBSA’s patented NAHYCO® Hybrid Technology. This technology thermally bonds high molecular weight HA (H-HA) and low molecular weight HA (L-HA) without the use of chemical cross-linking agents like BDDE.

The resulting stabilized hybrid cooperative complex (typically 64mg of HA in a 2ml prefilled syringe: 32mg H-HA + 32mg L-HA) is designed for multi-level tissue interaction. PROFHILO® H+L is intended to improve skin hydration, elasticity, and overall quality, addressing skin laxity and signs of aging by stimulating collagen and elastin production. This formulation does not contain lidocaine.

Storage: Store according to manufacturer guidelines, typically between 2°C and 25°C (36°F and 77°F). Do not freeze. Protect from light.

Authenticity: Health Supplies Plus guarantees that all PROFHILO® products sourced are authentic from the manufacturer or authorized distributors.

Note: For professional use only by trained and licensed practitioners familiar with bioremodelling techniques and the specific BAP (Bio Aesthetic Points) injection protocol.

How does PROFHILO® H+L work? (Based on Manufacturer Information)

PROFHILO® H+L’s NAHYCO® Hybrid Technology allows for a high concentration of HA that, once injected, exhibits high spreadability and diffuses extensively through the tissue layers. Its mechanism is described as “bioremodelling”:

1. Hydration (L-HA): The low molecular weight HA provides immediate and deep hydration, improving skin moisture and turgor.
2. Support & Biostimulation (H-HA): The high molecular weight HA provides a structural scaffold within the dermis and stimulates fibroblasts to produce new collagen (Type I, III, IV, VII) and elastin. This leads to a gradual improvement in skin firmness, elasticity, and overall tissue quality.

Unlike traditional fillers that primarily add volume to specific areas, PROFHILO® H+L aims to improve the overall health and architecture of the skin across a wider treatment zone. It is typically administered using the BAP technique (5 specific points per side of the face/neck) to maximize diffusion.

Optimal results are generally achieved after a course of two treatment sessions, spaced approximately one month apart. The effects are progressive, with noticeable improvements in skin hydration and radiance, followed by enhanced firmness and elasticity over several weeks. The manufacturer typically suggests results can last around 6 months, with maintenance treatments recommended.

Indications for Use (Common Applications)

Based on manufacturer information and common clinical use internationally, PROFHILO® H+L is typically indicated for adults seeking improvement in skin quality and addressing signs of laxity:

• Treatment of skin laxity on the face (particularly malar and submalar areas) and neck.
• Improving skin hydration, tone, and elasticity.
• Enhancing overall skin quality and radiance.
• Suitable for challenging areas like the inner arms, décolletage, and hands.

It is designed for skin bioremodelling and is not primarily a volumizing filler for correcting deep folds or providing significant structural augmentation. Appropriate patient selection is key, focusing on those with good skin quality but developing laxity and dehydration. Practitioners must consult the product IFU for detailed indications relevant to their region.

Primary Benefits (Based on Manufacturer Claims)

• Unique bioremodelling action through NAHYCO® Hybrid HA Technology.
• Improves skin hydration, elasticity, firmness, and overall quality.
• Addresses skin laxity, particularly in the face and neck.
• High HA concentration (64mg/2ml) without BDDE.
• High spreadability allows for treatment of larger areas with minimal injection points (BAP technique).
• Results claimed to last around 6 months after the initial course.
• Lidocaine-free formulation.

Side Effects and Safety Information

Practitioners must obtain and consult the complete product information provided by the manufacturer for comprehensive details on administration, contraindications, warnings, precautions, and potential adverse events before using this product. Discussing all potential risks and side effects with patients is essential. Proper injection technique (e.g., BAP points) and aseptic procedures are critical.

Common side effects expected with PROFHILO® H+L injections are typically mild, temporary, and related to the injection sites:

• Small papules or bumps at injection sites (characteristic of the BAP technique, usually resolve within hours to 1-2 days as product diffuses)
• Bruising
• Redness
• Mild swelling
• Tenderness or itching at injection points
• Slight hardness or inflammation at injection points

Severe Adverse Events:
While serious complications are rare with HA-based bioremodelling products when administered correctly, potential risks exist. Practitioners must be prepared to manage adverse events. Potential severe adverse events include:

• Vascular Occlusion (VO): Although the risk profile differs from deep bolus fillers and the BAP technique is designed for safety, accidental intravascular injection is theoretically possible. Practitioners must maintain anatomical awareness. Hyaluronidase should be available as for any HA injectable.
• Severe allergic reactions or hypersensitivity to HA
• Inflammation or infection at injection sites
• Persistent nodules or granuloma formation (very rare)
• Skin discoloration
• Herpetic eruptions (cold sores) in susceptible individuals

Any signs of vascular compromise, infection, hypersensitivity, or persistent adverse reactions require immediate medical evaluation.