HArmonyCa™

What is HArmonyCa™?

HArmonyCa™ is a sterile, injectable hybrid filler manufactured by Allergan, combining two distinct active substances: hyaluronic acid (HA) at 20 mg/mL and calcium hydroxyapatite (CaHA) at 55.7%, with 0.3% lidocaine hydrochloride for enhanced patient comfort. This dual-component formulation represents a distinct category of injectable — delivering both the immediate volumizing properties of a traditional HA filler and the long-term collagen-stimulating benefits of a CaHA biostimulator in a single product.

A clinically significant advantage of HArmonyCa™ over standalone CaHA products is its reversibility with hyaluronidase, made possible by the HA component. This provides practitioners with a critical management option not available with traditional calcium hydroxyapatite fillers.

HArmonyCa™ is indicated for deep subcutaneous or supraperiosteal injection for cheek augmentation, mid-face volumization, jawline definition, and temple restoration in adults.

Storage: Store between 2°C and 25°C (36°F and 77°F). Do not freeze. Protect from light.

Authenticity: Health Supplies Plus guarantees all HArmonyCa™ products are authentic, sourced through appropriate channels, and handled according to manufacturer specifications.

Note: For professional use only.

How does HArmonyCa™ work?

Age-related mid-face volume loss results from progressive bone resorption, fat pad deflation, and diminished collagen production. HArmonyCa™ addresses this through a two-phase mechanism of action that differentiates it from conventional HA fillers and standalone biostimulators alike.

Phase 1 — Immediate Volumization: Upon injection, the hyaluronic acid component delivers instant gel-based lift and volume, producing visible improvement in facial contours from the first treatment.

Phase 2 — Collagen Biostimulation: The calcium hydroxyapatite microspheres act as a biocompatible scaffold, stimulating fibroblast activity and promoting the gradual production of new endogenous collagen. As the CaHA is naturally resorbed over time, a strengthened collagen matrix remains — extending and enhancing results beyond what HA alone can achieve.

Results are visible immediately following treatment, with progressive improvement as collagen synthesis develops over subsequent weeks and months. Duration of effect can extend to 18 months or longer, though individual outcomes vary based on patient anatomy, age, metabolism, treatment area, and volume injected. The procedure is typically completed in 30 to 60 minutes. The integrated 0.3% lidocaine hydrochloride improves patient comfort throughout the injection process.

Who is an appropriate candidate for this treatment?

HArmonyCa™ is indicated for adults seeking correction of age-related mid-face volume loss and structural contour deficiencies, including cheek augmentation, jawline definition, and temple restoration. It is particularly well-suited for patients who would benefit from both immediate volumization and progressive collagen biostimulation — and for practitioners seeking the added clinical reassurance of hyaluronidase reversibility compared to standalone CaHA products.

Patient selection should be based on a thorough consultation and assessment of facial anatomy, treatment goals, and contraindications outlined in the product’s Instructions for Use (IFU).

Primary Benefits

• Hybrid dual-action formula — combines immediate HA volumization with CaHA collagen biostimulation in a single injectable treatment.
• Reversible with hyaluronidase — a critical safety and management advantage over standalone calcium hydroxyapatite products.
• Restores volume and structural support to the cheeks, mid-face, jawline, and temples.
• Progressive collagen stimulation produces results that continue to develop and extend over time.
• Long-lasting effects of up to 18 months or more.
• Formulated with 0.3% lidocaine hydrochloride for improved patient comfort during injection.
• Manufactured by Allergan to rigorous quality and safety standards.

Side Effects and Safety Information

Practitioners must consult the complete Instructions for Use (IFU) for comprehensive information on indications, contraindications, warnings, precautions, and potential adverse events. Discuss all potential risks and side effects with patients prior to treatment.

Common side effects are typically temporary and injection-site related:

• Tenderness or pain
• Swelling
• Bruising
• Redness
• Firmness or palpable lumps/nodules
• Itching
• Discoloration

Severe Adverse Events: As with any injectable filler involving deep tissue placement, there are risks of more serious complications. Practitioners must be trained in appropriate injection techniques and complication management protocols. Severe side effects, while rare, can include:

• Vascular Occlusion (VO): Accidental injection into a blood vessel can obstruct blood flow, potentially leading to tissue necrosis, scarring, or — in rare cases involving facial arteries — blindness or stroke. Thorough knowledge of deep facial anatomy is critical. Practitioners should have immediate access to hyaluronidase given the product’s HA component.
• Severe allergic reactions (anaphylaxis)
• Inflammation, infection, or abscess formation
• Granuloma or persistent nodule formation (associated with CaHA-containing products)
• Nerve damage or impingement due to deep injection placement
• Migration of filler material
• Prolonged pain or numbness
• Persistent swelling or hardness