ELLANSE™ S

Where can I buy this product?

ELLANSE™ S is available for purchase through Health Supplies Plus by licensed medical practitioners holding a valid medical license. First-time buyers can register an online account by providing required professional information, including medical license verification and a valid shipping address. Account verification is typically completed within 2 business hours, after which you can purchase medical supplies at competitive wholesale pricing. Registered members may also be eligible for volume discounts and receive dedicated customer service support. We are committed to ensuring all products are sourced and sold exclusively to qualified professionals.

Product Information

What is ELLANSE™ S?

ELLANSE™ S is a sterile, injectable, biostimulatory dermal filler manufactured by Sinclair Pharma. Its unique composition consists of synthetic Polycaprolactone (PCL) microspheres (30%) uniformly suspended in an aqueous Carboxymethylcellulose (CMC) gel carrier (70%), which also contains glycerin and phosphate buffered saline. It is latex-free and non-pyrogenic.

ELLANSE™ S is designed to provide both immediate correction of wrinkles and folds, and sustained volume restoration through the stimulation of the body’s own collagen production (neocollagenesis). The “S” designation in the Ellansé™ range indicates a specific PCL microsphere characteristic that results in a claimed duration of effect of approximately 1 year.

Storage: Store according to manufacturer guidelines, typically between 15°C and 25°C (59°F and 77°F). Do not freeze. Protect from light.

Authenticity: Health Supplies Plus guarantees that all ELLANSE™ products sourced are authentic from the manufacturer or authorized distributors.

Note: For professional use only by trained and licensed practitioners experienced in the use of biostimulatory fillers. Ellansé™ is NOT reversible with hyaluronidase.

How does ELLANSE™ S work? (Based on Manufacturer Information)

ELLANSE™ S offers a dual mechanism of action:

1. Immediate Correction: Upon injection, the CMC gel carrier provides immediate volume and lift, effectively correcting wrinkles, folds (such as nasolabial folds and marionette lines), and restoring facial contours. This initial volumizing effect from the gel lasts for several weeks to months before the gel is gradually resorbed.
2. Sustained Biostimulation (Neocollagenesis): The PCL microspheres act as a scaffold, initiating a controlled inflammatory response that stimulates fibroblasts to produce new Type I collagen. This new collagen gradually replaces the volume of the resorbed CMC gel carrier, providing a more durable and natural-looking restoration of volume and skin structure. The PCL microspheres themselves are also fully bioresorbable over the product’s intended duration.

This combination aims to deliver both immediate aesthetic improvement and long-term tissue regeneration for sustained results.

Indications for Use (Common Applications)

Based on its properties and common clinical use internationally, ELLANSE™ S is typically indicated for adults (generally over 21) seeking correction of facial wrinkles and volume restoration:

• Correction of moderate to severe facial wrinkles and folds (e.g., nasolabial folds, marionette lines).
• Facial contouring and volume augmentation (e.g., cheeks, temples, chin, jawline).
• Improving skin depressions or certain types of scars.
• Nasal reshaping (non-surgical rhinoplasty, requires advanced expertise).

It is **not** typically recommended for very superficial lines or direct injection into the lips (vermillion body) due to its biostimulatory nature and potential for palpability. Appropriate patient selection and deep dermal or subcutaneous injection techniques are crucial, based on the product IFU and specific training.

Primary Benefits (Based on Manufacturer Claims)

• Provides immediate wrinkle correction and volume from the CMC gel carrier.
• Stimulates natural collagen production (neocollagenesis) via PCL microspheres for sustained, long-term results.
• “S” formulation offers a predictable duration of effect around 1 year.
• Fully bioresorbable components (PCL and CMC).
• Versatile for addressing various facial aging concerns, from wrinkles to volume loss and contouring.
• May require fewer touch-up sessions compared to some short-acting HA fillers.

Side Effects and Safety Information

Practitioners must obtain and consult the complete product information/IFU provided by the manufacturer for comprehensive details on administration, contraindications, warnings, precautions, and potential adverse events before using this product. Discussing all potential risks and side effects with patients is essential, including the non-reversible nature with hyaluronidase. Advanced training in the use of biostimulatory fillers like Ellansé™ is highly recommended.

Common side effects expected with PCL-based filler injections include temporary, injection-site related reactions:

• Swelling (can be more pronounced and last longer than with some HA fillers)
• Bruising
• Redness
• Tenderness or Pain
• Itching
• Firmness or Palpable Lumps/Bumps/Nodules (early or delayed onset – require careful management if persistent)

Severe Adverse Events:
As with any dermal filler injection, particularly biostimulatory products requiring specific injection techniques, there are risks of more serious complications. Practitioners must be prepared to manage adverse events:

• Vascular Occlusion (VO): Accidental injection into a blood vessel can obstruct blood flow. Crucially, Ellansé™ is NOT reversible with hyaluronidase. Therefore, VO management relies on other emergency protocols, making prevention through meticulous technique and anatomical knowledge even more critical. VO can lead to tissue necrosis, scarring, or (rarely) blindness or stroke.
• Severe allergic reactions or hypersensitivity.
• Inflammation, infection, or abscess formation.
• Granuloma or persistent nodule formation (a known risk with biostimulators, requiring specific management).
• Migration of product (rare with proper technique).
• Prolonged pain or numbness.
• Herpetic eruptions (cold sores) in susceptible individuals.

Any signs of vascular compromise, infection, persistent nodules, or severe hypersensitivity require immediate medical evaluation and appropriate management, which may differ from HA filler complications due to the product’s nature.