ELLANSE™ M

Where can I buy this product?

ELLANSE™ M is available for purchase through Health Supplies Plus by licensed medical practitioners holding a valid medical license, for use only where legally permissible according to local and national regulations. First-time buyers can register an online account by providing required professional information, including medical license verification and a valid shipping address. Account verification is typically completed within 2 business hours, after which you can purchase medical supplies at competitive wholesale pricing. Registered members may also be eligible for volume discounts and receive dedicated customer service support. We are committed to ensuring all products are sourced and sold exclusively to qualified professionals.

Product Information

What is ELLANSE™ M?

ELLANSE™ M is a sterile, injectable, biostimulatory dermal filler manufactured by Sinclair Pharma. It is composed of synthetic Polycaprolactone (PCL) microspheres (30%) uniformly suspended in an aqueous Carboxymethylcellulose (CMC) gel carrier (70%), which also includes glycerin and phosphate buffered saline. It is latex-free and non-pyrogenic.

ELLANSE™ M is designed to provide both immediate correction of deep wrinkles and folds, and significant, sustained volume restoration through the stimulation of the body’s own natural collagen production (neocollagenesis). The “M” designation within the Ellansé™ product line indicates a specific PCL microsphere characteristic engineered to provide a longer duration of effect, with results typically lasting approximately 2 years.

Storage: Store according to manufacturer guidelines, typically between 15°C and 25°C (59°F and 77°F). Do not freeze. Protect from light.

Authenticity: Health Supplies Plus guarantees that all ELLANSE™ products sourced are authentic from the manufacturer or authorized distributors.

Note: For professional use only by trained and licensed practitioners experienced in the use of biostimulatory fillers. **Ellansé™ is NOT reversible with hyaluronidase.**

How does ELLANSE™ M work? (Based on Manufacturer Information)

ELLANSE™ M functions via a dual-action mechanism:

1. Immediate Volumization & Correction: Upon injection into the deep dermis or subcutaneous tissue, the CMC gel carrier provides immediate volume and lift, effectively correcting deep wrinkles, significant folds (such as severe nasolabial folds or marionette lines), and restoring facial contours. This initial effect from the gel carrier is gradually resorbed by the body over several weeks to months.
2. Sustained Biostimulation (Neocollagenesis): The PCL microspheres act as a biocompatible scaffold, initiating a controlled, physiological response that stimulates local fibroblasts to produce new Type I collagen. This newly synthesized collagen gradually replaces the volume of the resorbed CMC gel, providing durable, natural-looking structural support and volume restoration. The PCL microspheres themselves are fully bioresorbable, with their degradation timed to achieve the product’s intended 2-year longevity.

This combined approach aims to deliver both immediate aesthetic improvement and long-term tissue regeneration for robust and enduring results.

Indications for Use (Common Applications)

Based on its properties and common clinical use internationally, ELLANSE™ M is typically indicated for adults (generally over 21) seeking significant and long-lasting correction of facial volume loss and deep wrinkles:

• Correction of severe facial wrinkles and deep folds.
• Significant facial contouring and volume augmentation (e.g., cheeks, temples, chin, jawline).
• Restoration of substantial volume loss due to aging or other factors.
• Improving deep skin depressions or certain types of atrophic scars.
• Nasal reshaping (non-surgical rhinoplasty, requires advanced expertise and deep understanding of this non-reversible product).

It is **not** typically recommended for superficial lines or direct injection into the lips due to its robust nature and potential for palpability. Appropriate patient selection, deep dermal or subcutaneous injection techniques, and consideration of contraindications are crucial, based on the product IFU and specific advanced training.

Primary Benefits (Based on Manufacturer Claims)

• Provides both immediate correction and long-term volume through collagen biostimulation.
• “M” formulation offers an extended duration of effect, typically lasting around 2 years.
• Stimulates natural collagen production for sustained, natural-looking results.
• Fully bioresorbable components (PCL and CMC).
• Suitable for addressing significant facial volume loss and deep structural contouring.
• May offer longer intervals between treatments compared to shorter-acting fillers.

Side Effects and Safety Information

Practitioners must obtain and consult the complete product information/IFU provided by the manufacturer for comprehensive details on administration, contraindications, warnings, precautions, and potential adverse events before using this product. Discussing all potential risks and side effects with patients is essential, including the non-reversible nature with hyaluronidase and the longer duration of potential side effects. Advanced training in the use of biostimulatory fillers like Ellansé™ is highly recommended.

Common side effects expected with PCL-based filler injections, especially deep placement, include temporary, injection-site related reactions:

• Swelling (can be more pronounced and last longer than with some HA fillers)
• Bruising
• Redness
• Tenderness or Pain
• Itching
• Firmness or Palpable Lumps/Bumps/Nodules (early or delayed onset – require careful monitoring and management if persistent)

Severe Adverse Events:
As with any dermal filler injection, particularly biostimulatory products requiring specific deep injection techniques, there are risks of more serious complications. Practitioners must be prepared to manage adverse events:

• Vascular Occlusion (VO): Accidental injection into a blood vessel can obstruct blood flow. Crucially, Ellansé™ M is NOT reversible with hyaluronidase. Therefore, VO management relies on other emergency protocols, making prevention through meticulous technique and anatomical knowledge even more critical. VO can lead to severe tissue necrosis, scarring, or (rarely) blindness or stroke.
• Severe allergic reactions or hypersensitivity.
• Inflammation, infection, or abscess formation.
• Granuloma or persistent nodule formation (a known risk with biostimulators, requiring specific management strategies that may differ from HA nodules).
• Migration of product (rare with proper technique).
• Prolonged pain or numbness.
• Herpetic eruptions (cold sores) in susceptible individuals.

Any signs of vascular compromise, infection, persistent nodules, or severe hypersensitivity require immediate medical evaluation and appropriate management, which may be more complex due to the product’s non-reversible nature.