Karisma: The First Rh Collagen Softfiller for Bio-Restitution

As aesthetic science evolves, the focus shifts from merely filling wrinkles to actively rebuilding the skin’s depleted structural framework. The loss of type I collagen is a primary cause of dermal aging, leading to reduced elasticity and visible laxity. Addressing this requires a solution that can replenish these foundational building blocks.

Karisma, by the Italian pharmaceutical company Taumedika Srl, introduces a new category of injectable: the bio-restitutive softfiller. Harnessing the power of Recombinant Human Collagen, Karisma is engineered to offer a true “reconstruction” of the dermal matrix, restoring firmness and structure in a way that is both natural and biocompatible.

The Karisma Philosophy: A Trifecta of Dermal Reconstruction

Unlike traditional biostimulators that only signal the body to produce collagen, the Karisma philosophy is centered on a comprehensive, three-pronged approach: Rebuild, Hydrate, and Protect. This is achieved through a unique and synergistic combination of three key ingredients that work together to restore the skin’s integrity.

This intelligent formulation doesn’t just stimulate; it provides the essential building blocks for rejuvenation while protecting them from degradation, leading to more efficient and durable results.

The Cornerstone Product: Karisma RH Collagen FACE

The flagship of the Karisma range is the Karisma RH Collagen FACE softfiller, a Class III medical device that perfectly embodies the brand’s advanced scientific approach.

• Recombinant Human Collagen (Rh Collagen): The primary rebuilding agent. This non-immunogenic, animal-free type I collagen is produced via innovative silkworm technology, providing the perfect scaffolding to restore skin structure and firmness.
• High Molecular Weight Hyaluronic Acid: The hydration and proliferation matrix. It delivers immediate hydration and creates the ideal environment for fibroblasts to thrive and produce new dermal components.
• Carboxymethyl Cellulose (CMC): The protective shield. This anti-aging agent has an inhibitory effect on the enzyme hyaluronidase, protecting both the patient’s native and the injected hyaluronic acid from rapid degradation.

Patient Suitability & Contraindications

Karisma is an ideal treatment for patients showing signs of mild to moderate skin laxity, fine lines, and scarring. It is exceptionally effective for those seeking a natural improvement in skin firmness and texture. As a non-animal derived collagen, it has a high safety profile.

However, treatment is contraindicated in individuals with known hypersensitivity to any of the components, those with active skin infections, autoimmune disorders, or who are pregnant or breastfeeding.

Treatment Protocol & Post-Treatment Care

The Karisma protocol is straightforward and designed for optimal bio-restitution.

• Initial Course: A cycle of 2 sessions, spaced 30 days apart, is recommended.
• Maintenance: A follow-up treatment is advised after 4 months to maintain the results. The full protocol can be repeated every 6-12 months.
• Post-Treatment Advice: Standard aftercare applies. Patients should avoid strenuous activity, excessive heat, and alcohol for 24-48 hours to minimize potential bruising or swelling.

Expected Results & Duration

Results from Karisma are both immediate and progressive. Patients will notice an initial improvement in hydration and skin texture, with the full firming and lifting effects developing over the weeks following treatment as the Rh Collagen integrates and stimulates the dermis. The effects are long-lasting and remarkably natural, with results typically maintained for 6-12 months.

Advanced Technology & Quality Assurance

Karisma is a CE-marked medical device, manufactured in Italy under strict quality control standards. The use of innovative biotechnology to produce Recombinant Human Collagen from silkworms represents a significant step forward in aesthetic medicine, offering practitioners a safe, effective, and ethically produced tool for advanced skin rejuvenation.