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Juvederm Vs. Restylane: What’s The Difference?
Juvederm Vs. Restylane

To the uninformed, Juvederm and Restylane appear to be very similar.  For instance, both injectable dermal fillers use hyaluronic acid to achieve a volume replacement in the skin, resulting in wrinkle reduction and a lifting of the skin. Both treatments are non-surgical in nature, require no downtime and are virtually pain free. Finally, they both are ideal for use in similar facial areas to correct similar aging symptoms.

However, there are a few key differences between Juvederm and Restylane. This article provides an overview of the benefits and weaknesses of each filler.


The core formulas of Juvederm and Restylane is the same active ingredient: hyaluronic acid (HA). Hyaluronic acid is a natural molecule found in all human cells. HA is a well-known humectant, meaning it has the ability to attract and retain moisture. In fact, it can hold up to 1,000 times its weight in water. This unique ability is what allows both fillers to increase volume and plump the skin. And because the hyaluronic acid found in both Juvederm and Restylane are naturally occurring, there is little-to-no risk of allergic reactions among patients.


The primary difference between Restylane and Juvederm is their texture. Restylane is granular and more cohesive, while Juvederm has a more smooth texture. These texture differences provide both fillers different strengths. The smoothness of Juvederm makes it somewhat better at addressing finer lines and wrinkles in tight facial areas. On the flip side, the cohesive nature of Restylane allows it to remain in the injection area, which makes it ideal for adding volume in specific sunken facial areas. Restylane is also moldable, which allows the injector to better create shapes and contours to ‘rebuild’ certain facial areas.

Treatment Areas

As noted above, Restylane and Juvederm both have different formulas which target different facial areas. Juvederm can be used to address numerous areas of the face including the eyes, cheeks, and mouth area. The Juvederm family includes Juvederm Ultra (the original Juvederm formula), Juvederm Voluma (FDA approved to enhance cheek volume), Juvederm Volbella (designed for targeting lip lines and other fine lines around the mouth), and Juvederm Vollure (formulated to target severe folds and wrinkles included the nasolabial folds).

Restylane can be used to address many of the same facial areas as Juvederm, but it is particularly effective in treating the lips, cheeks, and area around the nose. As a unique feature, Restylane can be used to for hand rejuvenation by adding volume to the back of the hands. The Restylane family includes Restylane Silk (for the lips), Restylane Lyft (best for mid-face, cheeks, nasolabial folds), and Restylane Refyne and Defyne (to address more severe wrinkles).

Restylane and Juvederm


Juvederm and Restylane have the ability to provide dramatic results for most patients, reducing lines and wrinkles while boosting volume to make the skin firmer and plumper in appearance. Juvederm actually work slightly quicker, as its results are apparent immediately whereas the results of Restylane can take a day or so to take full effect.

How Long Do Results Last

Comparing result duration between dermal fillers can be difficult as many variables beyond filler type including the treatment area and the patient’s metabolism play key roles. Clinical results find that these fillers can last anywhere between 9 to 12 months.

The hyaluronic acid found in both formulas is biodegradable which is why results are non-permanent, and over time the body will naturally break down and absorb the injected hyaluronic acid, returning the treatment area to its pre-treatment state. Patients can choose to maintain the results of Restylane and Juvederm by undergoing periodic maintenance treatments over time, as required.


Patients experience little to no pain during a dermal filler treatment, especially when it is performed by a skilled injector. Juvederm and Restylane procedures are non-surgical and minimally invasive, and the filler is administered through a series of injections using an ultra-fine needle. In addition, many formulas in both families contain lidocaine, which numbs the skin during injection to minimize any discomfort. Added topical numbing cream can also be applied if requested by the patient.

Treatment Time

Dermal filler treatments such as Juvederm and Restylane are extremely quick and can even be performed during a patient’s lunch hour. While treatment time can differ, generally speaking, most patients will be in and out of the office within 30 to 45 minutes.


There is no downtime associated with either Juvederm or Restylane treatment. Patients can return to their normal daily activities directly following the procedure. It’s recommended that patients refrain from working out for 24 hours, to help decrease any post-procedure swelling.

Side Effects

Potential side effect for both treatments are relatively minor and typically resolve themselves without any intervention. Common side effects include bruising, swelling, redness, rash, or minor pain around the site of the injection. Note that serious side effects are rare and can include allergic reactions, changes to skin color, infection, numbness, and scarring.


Restylane and Juvederm pricing is comparable. However, the cost of any filler procedure can vary greatly depending on the particular needs of each patient. The procedure cost for either treatment is contingent on the amount of filler needed to accomplish the patient’s desired aesthetic outcome.

Juvederm Vs. Restylane: Which Is Better?

So which dermal filler is better? The answer is a simple “it depends”. While it’s always good for patients to understand the differences and benefits of each filler, the final decision on which filler is best for you should be left up to a skilled injector. An experienced provider will be able to assess your individual needs and desired outcomes, in order to develop the best course of treatment. In fact, it’s not uncommon for injectors to recommend using a combination of both fillers to create the patient’s desired look.

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